Credit: The Cre for the Development of Innovative Therapies for Psychiatric Disorders

Plasma neurofilament light protein is differentially associated with age in individuals with treatment-resistant schizophrenia and bipolar affective disorder compared to controls

Cassandra MJ Wannan, Dhamidhu Eratne, Alexander F Santillo, Charles Malpas, Brandon Cilia, Olivia M Dean, Adam Walker, Michael Berk, Chad Bousman, Ian Everall, Dennis Velakoulis, Christos Pantelis

2024-09-01

Accelerated brain ageing has been observed in multiple psychiatric disorders. This study examined whether relationships between ag..

Minocycline as Treatment for Psychiatric and Neurological Conditions: A Systematic Review and Meta-Analysis

B Panizzutti, D Skvarc, S Lin, S Croce, A Meehan, CC Bortolasci, W Marx, AJ Walker, K Hasebe, BE Kavanagh, MJ Morris, M Mohebbi, A Turner, L Gray, L Berk, K Walder, M Berk, OM Dean

2023-03-01

Minocycline has anti-inflammatory, antioxidant, and anti-apoptotic properties that explain the renewed interest in its use as an a..

Adjunctive minocycline for major depressive disorder: A sub-study exploring peripheral immune-inflammatory markers and associated treatment response

AJ Walker, M Mohebbi, M Maes, M Berk, K Walder, CC Bortolasci, ZS Liu, CH Ng, MM Ashton, L Berk, AB Singh, GS Malhi, OM Dean

2023-02-01

Background: Adjunctive minocycline shows promise in treating affective and psychotic disorders; however, the therapeutic mechanism..

Metformin is Protective Against the Development of Mood Disorders

J Lake, CC Bortolasci, AL Stuart, JA Pasco, S Kidnapillai, B Spolding, TTT Truong, B Panizzutti, ZSJ Liu, OM Dean, T Crowley, M Richardson, JH Kim, M Berk, LJ Williams, K Walder

2023-01-01

Introduction Mood disorders are a major cause of disability, and current treatment options are inadequate for reducing the burden ..

The role of metformin as a treatment for neuropsychiatric illness

S Dodd, L Sominsky, D Siskind, CC Bortolasci, AF Carvalho, M Maes, AJ Walker, K Walder, AR Yung, LJ Williams, H Myles, T Watson, M Berk

2022-11-01

Advances in psychopharmacology have been significantly slower to evolve than in other disciplines of medicine and therefore invest..

Integrative Analyses of Transcriptomes to Explore Common Molecular Effects of Antipsychotic Drugs

TTT Truong, CC Bortolasci, S Kidnapillai, B Spolding, B Panizzutti, ZSJ Liu, JH Kim, OM Dean, MF Richardson, M Berk, K Walder

2022-07-01

There is little understanding of the underlying molecular mechanism(s) involved in the clinical efficacy of antipsychotics for sch..

Co-Expression Networks Unveiled Long Non-Coding RNAs as Molecular Targets of Drugs Used to Treat Bipolar Disorder

TTT Truong, CC Bortolasci, B Spolding, B Panizzutti, ZSJ Liu, S Kidnapillai, M Richardson, L Gray, CM Smith, OM Dean, JH Kim, M Berk, K Walder

2022-04-08

Long non-coding RNAs (lncRNAs) may play a role in psychiatric diseases including bipolar disorder (BD). We investigated mRNA-lncRN..

Clinical High Risk for Psychosis - Not Seeing the Trees for the Wood

PD McGorry, B Nelson

2020-07-01